The only recurring crash potential is, as many other said, quitting the program, and even more likely closing a session and loading another as well as doing a realtime export (I have to because I use hardware inserts).Same here on OSX El Capitain. On my fairly potent Win 10 machine, 32c v5 is running very solid. Also, I know some people are content to stick with regular Mixbus and don't need the extras in 32C, but for me it's a game changer having two peak bands per channel. Overall, though, I'd say it's a fantastic DAW with a lot of great features. It doesn't seem like there's any relation to particular plugin companies, more just the act of bypassing and un-bypassing causes something in Mixbus to go haywire. I've read that v5 is more stable than past versions, but it seems that in my case at least there are still some kinks to work out regarding third party plugins. Auto-save has been reliable and I save constantly so I never really lose any work, but it's still a drag. For ex, if I'm auditioning a few different mix bus compressors (or even just one) and moving between them, I'm very very likely to crash. The vast majority of the time they happen when bypassing and un-bypassing plugins. I will say though, and I know that this has been a recurring complaint amongst Mixbus users, I do get a fair amount of crashes. Polarity optimization is insanely useful, as well as the spill feature. Loving it! The workflow is really quick and intuitive, and the channel EQ sounds awesome. Trying to use it as my main DAW for hiphop production-my MIDI needs are fairly minimal, mostly just drawing in 808 basslines, and I mostly work directly with audio samples for all my drums.

I've mostly used Logic in the past, and I've used Reaper and regular Mixbus a little bit as well.

Reaper vs mixbus